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Literature summary extracted from

  • Li, X.; Qian, S.; Zheng, L.; Yang, B.; He, Q.; Hu, Y.
    A mechanism-based fluorescent probe for labeling O6-methylguanine-DNA methyltransferase in live cells (2012), Org. Biomol. Chem., 10, 3189-3191.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.63 DNA (containing 6-O-methylguanine) + protein L-cysteine Homo sapiens
-
 DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.63 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.63 HeLa S3 cell
-
 Homo sapiens
-
2.1.1.63 HT-29 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.63 DNA (containing 6-O-benzylguanine) + protein L-cysteine
-
 Homo sapiens DNA (without 6-O-benzylguanine) + protein S-benzyl-L-cysteine
-
 ?
2.1.1.63 DNA (containing 6-O-methylguanine) + protein L-cysteine
-
 Homo sapiens DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
-
 ?
2.1.1.63 [N-[2-(2-[2-[(3-[[(2-amino-9H-purin-6-yl)oxy]methyl]phenyl)methoxy]ethoxy]ethoxy)ethyl]-5-(3,5-dimethyl-1H-pyrrol-2-yl-kappaN)-5-(3,5-dimethyl-2H-pyrrol-2-ylidene-kappaN)pentanamidato](difluoro)boron + [protein]-L-cysteine
-
 Homo sapiens [protein]-S-methyl-L-cysteine + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.63 MGMT
-
 Homo sapiens
2.1.1.63 O6-methylguanine-DNA methyltransferase
-
 Homo sapiens